概述

  • 产品名称Anti-AMELX抗体
    参阅全部 AMELX 一抗
  • 描述
    兔多克隆抗体to AMELX
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Mouse, Rat
  • 免疫原

    A synthetic peptide corresponding to N-terminal residues of mouse AMELX.

性能

应用

Our Abpromise guarantee covers the use of ab54507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
  • 疾病相关Defects in AMELX are the cause of amelogenesis imperfecta hypoplastic type 1 (AIH1) [MIM:301200]. AIH1 is a X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small.
  • 序列相似性Belongs to the amelogenin family.
  • 发展阶段Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the predominant protein in developing dental enamel.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI1E antibody
    • AIH1 antibody
    • ALGN antibody
    • Amel antibody
    • Amelogenesis imperfecta 1 antibody
    • Amelogenin (amelogenesis imperfecta 1, X linked) antibody
    • Amelogenin (X chromosome) antibody
    • Amelogenin (X chromosome, amelogenesis imperfecta 1) antibody
    • Amelogenin antibody
    • Amelogenin X isoform antibody
    • Amelogenin, X linked antibody
    • AMELX antibody
    • AMELX_HUMAN antibody
    • Amg antibody
    • AMGL antibody
    • AMGX antibody
    • OTTHUMP00000022906 antibody
    • OTTHUMP00000022907 antibody
    • X isoform antibody
    see all

Anti-AMELX antibody (ab54507)参考文献

This product has been referenced in:
  • Mazumder P  et al. Amelogenin-Ameloblastin Spatial Interaction around Maturing Enamel Rods. J Dent Res 95:1042-8 (2016). Read more (PubMed: 27146703) »
  • Lacruz RS  et al. Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol 227:2264-75 (2012). Read more (PubMed: 21809343) »

See all 2 Publications for this product

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