概述

  • 产品名称Anti-ALX4抗体
    参阅全部 ALX4 一抗
  • 描述
    兔多克隆抗体to ALX4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Guinea pig, Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 151-200 (EPELPPDSEP VGMDNSYLSV KETGAKGPQD RASAEIPSPL EKTDSESNKG) of Mouse ALX4 (NP_031468).

  • 阳性对照
    • Mouse brain tissue lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab104298 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
  • 组织特异性Expression is likely to be restricted to bone. Found in parietal bone.
  • 疾病相关Defects in ALX4 are the cause of parietal foramina 2 (PFM2) [MIM:609597]; also known as foramina parietalia permagna (FPP). PFM2 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. PFM2 is also a clinical feature of Potocki-Shaffer syndrome.
    Defects in ALX4 are the cause of frontonasal dysplasia type 2 (FND2) [MIM:613451]. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
    Involved in Potocki-Shaffer syndrome (PSS) [MIM:601224]. PSS is a contiguous gene syndrome caused by deletion of the 11p11.2 region.
  • 序列相似性Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alx4 antibody
    • ALX4_HUMAN antibody
    • Aristaless like homeobox 4 antibody
    • FND2 antibody
    • FPP antibody
    • homeobox protein aristaless like 4 antibody
    • Homeobox protein aristaless-like 4 antibody
    • homeodomain transcription factor ALX4 antibody
    • KIAA1788 antibody
    • PFM1 antibody
    • PFM2 antibody
    see all

Anti-ALX4 antibody 图像

  • Anti-ALX4 antibody (ab104298) at 1 µg/ml + Mouse brain tissue lysate at 10 µg

    Predicted band size : 44 kDa

Anti-ALX4 antibody (ab104298)参考文献

ab104298 has not yet been referenced specifically in any publications.

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