概述

  • 产品名称Anti-Alx1抗体
    参阅全部 Alx1 一抗
  • 描述
    兔多克隆抗体to Alx1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MEFLSEKFAL KSPPSKNSDF YMGTGGALEH VMETLDNESF YGKATAGKCV) of Mouse Alx1 (NP_766141).

  • 阳性对照
    • Mouse Heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab105772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development.
  • 组织特异性Cartilage and cervix tissue.
  • 疾病相关Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3) [MIM:613456]. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
  • 序列相似性Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 翻译后修饰Acetylated at Lys-131 by EP300, leading to increased interaction with EP300 and enhances transcriptional activation activity.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALX homeobox 1 antibody
    • ALX homeobox protein 1 antibody
    • ALX1 antibody
    • ALX1_HUMAN antibody
    • CART 1 antibody
    • CART-1 antibody
    • CART1 antibody
    • Cartilage homeoprotein 1 antibody
    • Cartilage paired class homeoprotein 1 antibody
    • FND3 antibody
    see all

Anti-Alx1 antibody 图像

  • Anti-Alx1 antibody (ab105772) at 1 µg/ml + Mouse Heart lysate at 10 µg

    Predicted band size : 37 kDa

Anti-Alx1 antibody (ab105772)参考文献

ab105772 has not yet been referenced specifically in any publications.

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