概述

  • 产品名称Anti-Als2抗体
    参阅全部 Als2 一抗
  • 描述
    小鼠单克隆抗体to Als2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: PSQDLKPVPE RCNQCSQLLI TMTDKEDHVI ISDSHCCPLG VTLTESQAEN HASTALSPST ETLDRQEEVF ENTLVANDQS VATELNAVSA QITSSDAMSS , corresponding to amino acids 221-321 of Human Als2

性能

应用

Our Abpromise guarantee covers the use of ab57550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
    • 疾病相关Defects in ALS2 are the cause of amyotrophic lateral sclerosis type 2 (ALS2) [MIM:205100]. ALS2 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
      Defects in ALS2 are the cause of juvenile primary lateral sclerosis (JPLS) [MIM:606353]. JPLS is a neurodegenerative disorder which is closely related to but clinically distinct from amyotrophic lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the upper motor neurons of the motor cortex while the lower neurons are unaffected.
      Defects in ALS2 are the cause of infantile-onset ascending spastic paralysis (IAHSP) [MIM:607225]. IAHSP is characterized by progressive spasticity and weakness of limbs.
    • 序列相似性Contains 1 DH (DBL-homology) domain.
      Contains 8 MORN repeats.
      Contains 1 PH domain.
      Contains 5 RCC1 repeats.
      Contains 1 VPS9 domain.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ALS 2 antibody
      • ALS2 antibody
      • ALS2_HUMAN antibody
      • ALS2CR6 antibody
      • Alsin antibody
      • ALSJ antibody
      • Amyotrophic lateral sclerosis 2 (juvenile) antibody
      • Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 6 antibody
      • Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein antibody
      • Amyotrophic lateral sclerosis 2 protein antibody
      • Amyotrophic lateral sclerosis protein 2 antibody
      • FLJ31851 antibody
      • IAHSP antibody
      • KIAA1563 antibody
      • MGC87187 antibody
      • PLSJ antibody
      see all

    Anti-Als2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57550 Als2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-Als2 antibody (ab57550)参考文献

    ab57550 has not yet been referenced specifically in any publications.

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