Anti-alpha smooth muscle Actin抗体[1A4],prediluted (ab8207)

概述

  • 产品名称
    Anti-alpha smooth muscle Actin抗体[1A4],prediluted
    参阅全部 alpha smooth muscle Actin 一抗
  • 描述
    小鼠单克隆抗体[1A4] to alpha smooth muscle Actin,prediluted
  • 宿主
    Mouse
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Cow, Pig, Frog
  • 免疫原

    Synthetic peptide corresponding to Human alpha smooth muscle Actin (N terminal).
    Database link: P62736

  • 阳性对照
    • IHC: Human small intestine tissue.
  • 常规说明

    This antibody reacts with smooth muscle cells of blood vessels and parenchymal tissue of intestine, testis and ovary.

    To identify and differentiate tumors of myogenic origin.

     

性能

应用

Our Abpromise guarantee covers the use of ab8207 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.

靶标

  • 功能
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 疾病相关
    Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
  • 序列相似性
    Belongs to the actin family.
  • 细胞定位
    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • a actin antibody
    • AAT6 antibody
    • ACTA_HUMAN antibody
    • ACTA2 antibody
    • Actin alpha 2 smooth muscle aorta antibody
    • Actin aortic smooth muscle antibody
    • Actin, aortic smooth muscle antibody
    • ACTSA antibody
    • ACTVS antibody
    • Alpha 2 actin antibody
    • Alpha actin 2 antibody
    • Alpha cardiac actin antibody
    • alpha sma antibody
    • Alpha-actin-2 antibody
    • Cell growth inhibiting gene 46 protein antibody
    • Cell growth-inhibiting gene 46 protein antibody
    • GIG46 antibody
    • Growth inhibiting gene 46 antibody
    • MYMY5 antibody
    see all

图片

  • Formalin-fixed, paraffin-embedded human small intestine tissue stained for alpha smooth muscle Actin using ab8207 in immunohistochemical analysis.

文献

This product has been referenced in:
  • Ikutani M  et al. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy. JCI Insight 2:e90721 (2017). Read more (PubMed: 28405615) »
  • Li M  et al. Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-?. Am J Cardiovasc Dis 6:118-28 (2016). Read more (PubMed: 27679746) »

See all 2 Publications for this product

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