Anti-Alpha Skeletal Muscle Actin抗体[5C5.F8.C7], prediluted (ab52332)


  • 产品名称Anti-Alpha Skeletal Muscle Actin抗体[5C5.F8.C7], prediluted
    参阅全部 Alpha Skeletal Muscle Actin 一抗
  • 描述
    小鼠单克隆抗体[5C5.F8.C7] to Alpha Skeletal Muscle Actin, prediluted
  • 特异性This antibody is highly specific and shows no cross-reaction with smooth muscle actin. It reacts with sarcomeric actins of normal tissues and neoplasms derived from such tissues (i.e. rhabdomyosarcomas).
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Guinea pig
  • 免疫原

    A synthetic peptide derived from N-terminal of human alpha skeletal muscle isoform of actin; acetylated at the N-terminus.

  • 阳性对照
    • Skeletal muscle tissue



Our Abpromise guarantee covers the use of ab52332 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IHC-P: Ready-to-use for 30 min at RT. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
    • 疾病相关Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.
      Defects in ACTA1 are a cause of myopathy congenital with excess of thin myofilaments (MPCETM) [MIM:161800]. A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.
      Defects in ACTA1 are a cause of congenital myopathy with fiber-type disproportion (CFTD) [MIM:255310]; also known as congenital fiber-type disproportion myopathy (CFTDM). CFTD is a genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
    • 序列相似性Belongs to the actin family.
    • 细胞定位Cytoplasm > cytoskeleton.
    • Information by UniProt
    • 数据库链接
    • 别名
      • a actin antibody
      • ACTA antibody
      • ACTA1 antibody
      • ACTC antibody
      • ACTC1 antibody
      • Actin alpha cardiac muscle antibody
      • Actin, alpha skeletal muscle antibody
      • ACTS_HUMAN antibody
      • Alpha actin 1 antibody
      • Alpha-actin-1 antibody
      • ASMA antibody
      • Cardiac muscle alpha actin 1 antibody
      • MPFD antibody
      • Skeletal muscle alpha actin 1 antibody
      see all

    Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7], prediluted 图像

    • Skeletal muscle stained with ab52332.

    Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7], prediluted (ab52332)参考文献

    ab52332 has not yet been referenced specifically in any publications.

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