Irreversible antagonist of nicotinic acethylcholine receptors (nAChRs). 74-aa polypeptide derived from the venom of the banded krait, Bungarus multicinctus. Selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and >3 μM, respectively). Blocks neuromuscular transmission. Inhibits opening of nicotinic receptor-associated ion channels.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in any aqueous buffer. It is recommended that all preparations are centrifuged before use.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Marinou M & Tzartos SJ Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides. Biochem J372:543-54 (2003).
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Colquhoun LM & Patrick JW Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmacol39:191-220 (1997).
Read more (PubMed: 9160116) »