Anti-Alpha B Crystallin (phospho S45)抗体(ab5598)

概述

  • 产品名称Anti-Alpha B Crystallin (phospho S45)抗体
    参阅全部 Alpha B Crystallin 一抗
  • 描述
    兔多克隆抗体to Alpha B Crystallin (phospho S45)
  • 经测试应用适用于: IHC-P, WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human
    预测可用于: Sheep, Rabbit, Hamster, Pig, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide corresponding to Human Alpha B Crystallin aa 44-54.
    Sequence: LSpPFYLRPPSF

  • 阳性对照
    • Immunofluorescence staining of phospho-alpha-B crystallin (Ser45) in U373 MG cells results in cytoplasmic staining.

性能

应用

Our Abpromise guarantee covers the use of ab5598 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 8 µg/ml.
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.
ICC/IF Use a concentration of 5 µg/ml.

靶标

  • 功能May contribute to the transparency and refractive index of the lens.
  • 组织特异性Lens as well as other tissues.
  • 疾病相关Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.
  • 序列相似性Belongs to the small heat shock protein (HSP20) family.
  • 细胞定位Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AACRYA antibody
    • Alpha B crystallin antibody
    • Alpha crystallin B chain antibody
    • Alpha(B)-crystallin antibody
    • Alpha-crystallin B chain antibody
    • CRYA2 antibody
    • Cryab antibody
    • CRYAB_HUMAN antibody
    • Crystallin alpha B antibody
    • Crystallin alpha polypeptide 2 antibody
    • CTPP2 antibody
    • Heat shock 20 kD like protein antibody
    • Heat shock protein beta 5 antibody
    • Heat shock protein beta-5 antibody
    • HspB5 antibody
    • Renal carcinoma antigen NY REN 27 antibody
    • Renal carcinoma antigen NY-REN-27 antibody
    • Rosenthal fiber component antibody
    see all

Anti-Alpha B Crystallin (phospho S45) antibody 图像

  • Western blot of recombinant bovine phospho-alpha-B crystallin (Ser45) using ab5598. Lane 1 is phospho-alpha-B crystallin (Ser45) and lane 2 is unphosphorylated alpha-B crystallin.

Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)参考文献

This product has been referenced in:
  • Tanito M  et al. Diagnostic Western blot for lens-specific proteins in aqueous fluid after traumatic lens-induced uveitis. Jpn J Ophthalmol 53:436-9 (2009). Read more (PubMed: 19763765) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. Should yo...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"