The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明WB: Use at a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 18-19 kDa (predicted molecular weight: 20 kDa).
Peptide ELISA: antibody detection limit dilution 1:128,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能May contribute to the transparency and refractive index of the lens.
组织特异性Lens as well as other tissues.
疾病相关Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.
序列相似性Belongs to the small heat shock protein (HSP20) family.
细胞定位Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.