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RabMAb

Anti-alpha Actinin 4抗体[EPR4410] (ab108201)

概述

  • 产品名称
    Anti-alpha Actinin 4抗体[EPR4410]
    参阅全部 alpha Actinin 4 一抗
  • 描述
    兔单克隆抗体[EPR4410] to alpha Actinin 4
  • 经测试应用
    适用于: WB, IP, IHC-Pmore details
    不适用于: Flow Cyt or ICC
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human alpha Actinin 4.

  • 阳性对照
    • HeLa, MCF-7, C2C12, A673, and L6 cell lysates; Human kidney tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab108201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 100 kDa (predicted molecular weight: 105 kDa).
IP 1/10 - 1/100.
IHC-P 1/100 - 1/250.
  • 应用说明
    Is unsuitable for Flow Cyt or ICC.
  • 靶标

    • 功能
      F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
    • 组织特异性
      Widely expressed.
    • 疾病相关
      Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
    • 序列相似性
      Belongs to the alpha-actinin family.
      Contains 1 actin-binding domain.
      Contains 2 CH (calponin-homology) domains.
      Contains 2 EF-hand domains.
      Contains 4 spectrin repeats.
    • 细胞定位
      Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines.
    • Information by UniProt
    • 数据库链接
    • 别名
      • actinin 4 antibody
      • Actinin alpha 4 antibody
      • actinin4 antibody
      • ACTN 4 antibody
      • ACTN4 antibody
      • ACTN4_HUMAN antibody
      • Alpha-actinin-4 antibody
      • DKFZp686K23158 antibody
      • F actin cross linking protein antibody
      • F-actin cross-linking protein antibody
      • Focal segmental glomerulosclerosis 1 antibody
      • FSGS 1 antibody
      • FSGS antibody
      • FSGS1 antibody
      • Non muscle alpha actinin 4 antibody
      • Non-muscle alpha-actinin 4 antibody
      see all

    图片

    • All lanes : Anti-alpha Actinin 4 antibody [EPR4410] (ab108201) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : MCF-7 cell lysate
      Lane 3 : C2C12 cell lysate
      Lane 4 : A673 cell lysate
      Lane 5 : L6 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 105 kDa
    • ab108201, at 1/100 dilution, staining alpha Actinin 4 in paraffin-embedded Human kidney tissue by Immunohistochemistry.

    文献

    ab108201 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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