Anti-alpha A Crystallin抗体(ab69552)

概述

• 产品名称
  Anti-alpha A Crystallin抗体
  参阅全部 alpha A Crystallin 一抗
• 描述
  兔多克隆抗体to alpha A Crystallin
• 经测试应用
  适用于: WB, IPmore details
• 种属反应性
  与反应: Cow, Human
  预测可用于: Chicken
• 免疫原

  Synthetic peptide derived from sequence near the carboxy-terminus of human alpha A Crystallin, conjugated to KLH

• 阳性对照
  • Bovine alpha A Crystallin protein.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  Preservative: 0.09% Sodium Azide
  Constituents: 50% Glycerol, PBS, pH 7.2
• Concentration information loading...
• 纯度
  Protein A purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Signal Transduction
  • Protein Trafficking
  • Chaperones
  • Heat Shock Proteins

  • Tags & Cell Markers
  • Cell Type Markers
  • Other Cell Types

  • Neuroscience
  • Sensory System
  • Visual system

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  May contribute to the transparency and refractive index of the lens.
• 疾病相关
  Defects in CRYAA are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood.
• 序列相似性
  Belongs to the small heat shock protein (HSP20) family.
• 翻译后修饰
  O-glycosylated; contains N-acetylglucosamine side chains.
  Deamidation of Asn-101 in lens occurs mostly during the first 30 years of age, followed by a small additional amount of deamidation (approximately 5%) during the next approximately 38 years, resulting in a maximum of approximately 50% deamidation during the lifetime of the individual.
  Phosphorylation on Ser-122 seems to be developmentally regulated. Absent in the first months of life, it appears during the first 12 years of human lifetime. The relative amount of phosphorylated form versus unphosphorylated form does not change over the lifetime of the individual.
• 细胞定位
  Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

• Target information above from: UniProt accession P02489 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 281718 Cow
  • Entrez Gene: 1409 Human
  • Omim: 123580 Human
  • SwissProt: P02504 Chicken
  • SwissProt: P02470 Cow
  • SwissProt: P02489 Human
  • Unigene: 184085 Human
• 别名
  • Acry 1 antibody
  • Alpha crystallin A chain antibody
  • Alpha-crystallin A chain antibody

  • CRYA 1 antibody
  • CRYA1 antibody
  • CRYAA antibody
  • CRYAA_HUMAN antibody
  • Crystallin alpha 1 antibody
  • Crystallin alpha A antibody
  • Heat shock protein beta 4 antibody
  • Heat shock protein beta-4 antibody
  • HSPB 4 antibody
  • HspB4 antibody
  • short form antibody
  • Zonular Central Nuclear Cataract antibody

  see all

实验方案

• Western blot protocols
• Immunoprecipitation protocols