Anti-alpha A Crystallin抗体(ab69552)

概述

  • 产品名称Anti-alpha A Crystallin抗体
    参阅全部 alpha A Crystallin 一抗
  • 描述
    兔多克隆抗体to alpha A Crystallin
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Cow, Human
    预测可用于: Chicken
  • 免疫原

    Synthetic peptide derived from sequence near the carboxy-terminus of human alpha A Crystallin, conjugated to KLH

  • 阳性对照
    • Bovine alpha A Crystallin protein.

性能

应用

Our Abpromise guarantee covers the use of ab69552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 20 kDa.
IP 1/100.

靶标

  • 功能May contribute to the transparency and refractive index of the lens.
  • 疾病相关Defects in CRYAA are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood.
  • 序列相似性Belongs to the small heat shock protein (HSP20) family.
  • 翻译后修饰O-glycosylated; contains N-acetylglucosamine side chains.
    Deamidation of Asn-101 in lens occurs mostly during the first 30 years of age, followed by a small additional amount of deamidation (approximately 5%) during the next approximately 38 years, resulting in a maximum of approximately 50% deamidation during the lifetime of the individual.
    Phosphorylation on Ser-122 seems to be developmentally regulated. Absent in the first months of life, it appears during the first 12 years of human lifetime. The relative amount of phosphorylated form versus unphosphorylated form does not change over the lifetime of the individual.
  • 细胞定位Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acry 1 antibody
    • Alpha crystallin A chain antibody
    • Alpha-crystallin A chain antibody
    • CRYA 1 antibody
    • CRYA1 antibody
    • CRYAA antibody
    • CRYAA_HUMAN antibody
    • Crystallin alpha 1 antibody
    • Crystallin alpha A antibody
    • Heat shock protein beta 4 antibody
    • Heat shock protein beta-4 antibody
    • HSPB 4 antibody
    • HspB4 antibody
    • short form antibody
    • Zonular Central Nuclear Cataract antibody
    see all

Anti-alpha A Crystallin antibody 图像

  • Anti-alpha A Crystallin antibody (ab69552) at 1/1000 dilution + bovine alpha A Crystallin protein

    Predicted band size : 20 kDa
    Observed band size : 20 kDa
  • All lanes : Anti-alpha A Crystallin antibody (ab69552) at 1/1000 dilution

    Lane 1 : Crystalline, alpha native bovine protein
    Lane 2 : Crystalline alpha A native bovine protein
    Lane 3 : Crytalline alpha B native bovine protein
    Lane 4 : Crystalline beta native bovine protein


    Predicted band size : 20 kDa

Anti-alpha A Crystallin antibody (ab69552)参考文献

ab69552 has not yet been referenced specifically in any publications.

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