Anti-alpha A + alpha B Crystallin抗体(ab63998)

概述

  • 产品名称Anti-alpha A + alpha B Crystallin抗体
    参阅全部 Alpha A + alpha B Crystallin 一抗
  • 描述
    兔多克隆抗体to alpha A + alpha B Crystallin
  • 经测试应用适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Cow, Human
  • 免疫原

    Bovine alpha/beta crystalin which has greater than 80% homology with human alpha/beta crystalin.

  • 阳性对照
    • Stains Rosenthal fibre accumulation in astrocytes in human neurological trauma.

性能

应用

Our Abpromise guarantee covers the use of ab63998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1000 - 1/4000.
ICC/IF 1/100 - 1/400.

靶标

  • 相关性Crystallins are separated into two classes: taxon specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Alpha crystallins are composed of two gene products: alpha A and alpha B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture.
  • 细胞定位Cytoplasmic
  • 数据库链接
  • 别名
    • Alpha crystallin A chain antibody
    • Alpha crystallin B chain antibody
    • CRYA1 antibody
    • CRYA2 antibody
    • CRYAA antibody
    • CRYAB antibody
    • Heat shock protein beta 4 antibody
    • Heat shock protein beta 5 antibody
    • HspB4 antibody
    • HspB5 antibody
    • Rosenthal fiber component antibody
    see all

Anti-alpha A + alpha B Crystallin antibody 图像

  • Ab63998 (1:2000) staining of human brain tissue showing aß crystallin accumulation in Rosenthal fibres. Secondary antibody biotinylated Goat anti-rabbit (1/2000). (A) Shows the early stages of aß crystallin accumulation in astrocytes, (B) astrocyte begins to hypertrophy with aß crystallin accumulation, (C) the astrocyte begins to further hypertrophy and cell structure is lost.

Anti-alpha A + alpha B Crystallin antibody (ab63998)参考文献

ab63998 has not yet been referenced specifically in any publications.

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