Anti-alpha 2 Macroglobulin抗体[EPR4432] (ab109422)

概述

• 产品名称
  Anti-alpha 2 Macroglobulin抗体[EPR4432]
  参阅全部 alpha 2 Macroglobulin 一抗
• 描述
  兔单克隆抗体[EPR4432] to alpha 2 Macroglobulin
• 经测试应用
  适用于: WB, IHC-Pmore details
  不适用于: Flow Cyt,ICC or IP
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide corresponding to residues in Human alpha 2 Macroglobulin.

• 阳性对照
  • Human plasma lysate; Human liver tissue
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

  Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab^® patents

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 纯度
  Tissue culture supernatant
• 克隆
  单克隆
• 克隆编号
  EPR4432
• 同种型
  IgG
• 研究领域
  • Cardiovascular
  • Blood
  • Serum Proteins

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Protease inhibitors
  • Other protease inhibitors

应用

靶标

• 功能
  Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
• 组织特异性
  Secreted in plasma.
• 序列相似性
  Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
• 发展阶段
  Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.
• 细胞定位
  Secreted.

• Target information above from: UniProt accession P01023 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 2 Human
  • Omim: 103950 Human
  • SwissProt: P01023 Human
  • Unigene: 212838 Human
• 别名
  • A2m antibody
  • A2MG_HUMAN antibody
  • Alpha 2 M antibody

  • Alpha 2M antibody
  • Alpha-2-M antibody
  • Alpha-2-macroglobulin antibody
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody
  • CPAMD5 antibody
  • DKFZp779B086 antibody
  • FWP007 antibody
  • S863 7 antibody

  see all

实验方案

• Western blot protocols
• Immunohistochemistry protocols