Anti-alpha 2 Macroglobulin抗体(Biotin) (ab7338)

概述

  • 产品名称
    Anti-alpha 2 Macroglobulin抗体(Biotin)
    参阅全部 alpha 2 Macroglobulin 一抗
  • 描述
    山羊多克隆抗体to alpha 2 Macroglobulin (Biotin)
  • 偶联物
    Biotin
  • 经测试应用
    适用于: Immunomicroscopy, IP, WB, Dot blot, ELISA, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Alpha-2-Macroglobulin [Human Plasma]

  • 常规说明

    Biotinamidocaproate N-Hydroxysuccinimide Ester (BAC) Biotin/Protein Ratio: 10-20 BAC molecules per rabbit IgG molecule.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    pH: 7.60
    Preservative: 0.01% Sodium azide
    Constituents: 0.88% Sodium chloride, 1% BSA, 0.42% Potassium phosphate
  • Concentration information loading...
  • 纯度
    IgG fraction
  • 纯化说明
    This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab7338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Immunomicroscopy
IP
WB
Dot blot
ELISA
IHC-Fr
  • 应用说明
    Immunoblotting (western or dot blot)
    ELISA (1:9,000 to 1:36,000)
    Immunohistochemistry
    Immunomicroscopy
    as well as other antibody based assays using streptavidin or avidin conjugates requiring lot-to-lot consistency.
  • 靶标

    • 功能
      Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
    • 组织特异性
      Secreted in plasma.
    • 序列相似性
      Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
    • 发展阶段
      Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.
    • 细胞定位
      Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A2m antibody
      • A2MG_HUMAN antibody
      • Alpha 2 M antibody
      • Alpha 2M antibody
      • Alpha-2-M antibody
      • Alpha-2-macroglobulin antibody
      • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody
      • CPAMD5 antibody
      • DKFZp779B086 antibody
      • FWP007 antibody
      • S863 7 antibody
      see all

    文献

    This product has been referenced in:
    • Jensen PE  et al. Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis. Biochim Biophys Acta 1690:203-7 (2004). ELISA . Read more (PubMed: 15511627) »

    See 1 Publication for this product

    客户评价及客户问答

    Thank you for your enquiry. As these 4 antibodies are all polyclonal antibodies, each will recognize multiple epitopes. If you have any more questions, please do contact us again.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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