The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000. Predicted molecular weight: 105 kDa.
应用说明Is unsuitable for Flow Cyt or IHC-P.
功能May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
序列相似性Belongs to the vinculin/alpha-catenin family.
细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell projection > axon. Recruited to the nucleus upon ZNF639 overexpression.
Paul C & Robaire B Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases. PLoS One8:e84354 (2013).
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