Anti-alpha 1 Spectrin抗体[AF10] (ab86184)

概述

  • 产品名称Anti-alpha 1 Spectrin抗体[AF10]
    参阅全部 alpha 1 Spectrin 一抗
  • 描述
    小鼠单克隆抗体[AF10] to alpha 1 Spectrin
  • 特异性ab86184 is specific to the erythroid alpha 1 Spectrin.
  • 经测试应用适用于: WB, IP, ICCmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Ghost proteins of human red blood cells.

  • 常规说明


    ab86184 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.

性能

应用

Our Abpromise guarantee covers the use of ab86184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 280 kDa.
IP Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.

靶标

  • 功能Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
  • 疾病相关Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2) [MIM:130600]. EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
    Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3) [MIM:270970]; also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.
  • 序列相似性Belongs to the spectrin family.
    Contains 3 EF-hand domains.
    Contains 1 SH3 domain.
    Contains 21 spectrin repeats.
  • 细胞定位Cytoplasm > cytoskeleton. Cytoplasm > cell cortex.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha I spectrin antibody
    • EL 2 antibody
    • EL2 antibody
    • Elliptocytosis 2 antibody
    • Elliptocytosis2 antibody
    • Erythrocyte alpha spectrin antibody
    • erythrocyte antibody
    • Erythroid alpha spectrin antibody
    • Erythroid alpha-spectrin antibody
    • Erythroid spectrin alpha antibody
    • HPP antibody
    • HS3 antibody
    • Spectrin alpha chain antibody
    • Spectrin alpha chain erythrocyte antibody
    • Spectrin alpha erythrocytic 1 antibody
    • SPH3 antibody
    • SPTA 1 antibody
    • SPTA antibody
    • SPTA1 antibody
    • SPTA1_HUMAN antibody
    see all

Anti-alpha 1 Spectrin antibody [AF10] (ab86184)参考文献

ab86184 has not yet been referenced specifically in any publications.

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