概述

  • 产品名称Anti-Alpha 1 microglobulin抗体
    参阅全部 Alpha 1 microglobulin 一抗
  • 描述
    兔多克隆抗体to Alpha 1 microglobulin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide: ATLESYVVHT NYDEYAIFLT KKFSHRHGPT ITAKLYGREP QLRDSLLQEF , corresponding to N terminal amino acids 115-164 of Rat Alpha 1 microglobulin

  • 阳性对照
    • Rat lung lysate

性能

应用

Our Abpromise guarantee covers the use of ab110707 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
    Trypstatin is a trypsin inhibitor.
  • 组织特异性Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
  • 序列相似性In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
    Contains 2 BPTI/Kunitz inhibitor domains.
  • 翻译后修饰The precursor is proteolytically processed into separately functioning proteins.
    3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
    Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.
    Addition of glycosaminoglycan chondroitin sulfate, allows cross-linking between the different components.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A1M antibody
    • Alpha 1 microglobulin/bikunin precursor antibody
    • Alpha 1 microglycoprotein antibody
    • Alpha-1 microglycoprotein antibody
    • Alpha-1-microglobulin antibody
    • AMBP antibody
    • AMBP_HUMAN antibody
    • Bikunin antibody
    • Complex-forming glycoprotein heterogeneous in charge antibody
    • EDC1 antibody
    • Growth inhibiting protein 19 antibody
    • HCP antibody
    • HI-30 antibody
    • HI30 antibody
    • IATIL antibody
    • ITI antibody
    • ITI-LC antibody
    • ITIL antibody
    • Microglobulin (alpha 1) antibody
    • Protein AMBP antibody
    • Protein HC antibody
    • Trypstatin antibody
    • Uristatin antibody
    • Uronic-acid-rich protein antibody
    • UTI antibody
    see all

Anti-Alpha 1 microglobulin antibody 图像

  • Anti-Alpha 1 microglobulin antibody (ab110707) at 1 µg/ml + Rat lung lysate at 10 µg

    Predicted band size : 39 kDa

Anti-Alpha 1 microglobulin antibody (ab110707)参考文献

This product has been referenced in:
  • Zhao M  et al. Dynamic changes of urinary proteins in a focal segmental glomerulosclerosis rat model. Proteome Sci 12:42 (2014). WB ; Rat . Read more (PubMed: 25061428) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"