Anti-alpha 1 Glycine Receptor抗体(ab26134)

概述

  • 产品名称Anti-alpha 1 Glycine Receptor抗体
    参阅全部 alpha 1 Glycine Receptor 一抗
  • 描述
    兔多克隆抗体to alpha 1 Glycine Receptor
  • 特异性ab26134 recognises Glycine receptor alpha-1 chain precursor (GLRA1).
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Zebrafish
  • 免疫原

    Synthetic peptide derived from a region between residues 178 - 227 of human Glycine Receptor alpha 1.

    .

  • 阳性对照
    • Raji cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab26134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/62500.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
  • 疾病相关Defects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GLRA1 antibody
    • GLRA1_HUMAN antibody
    • Glycine receptor 48 kDa subunit antibody
    • Glycine receptor alpha 1 antibody
    • Glycine receptor strychnine-binding subunit antibody
    • Glycine receptor subunit alpha-1 antibody
    • Glycine receptor, alpha 1 subunit antibody
    • HKPX1 antibody
    • STHE antibody
    see all

Anti-alpha 1 Glycine Receptor antibody 图像

  • Anti-alpha 1 Glycine Receptor antibody (ab26134) at 1 µg/ml + Raji cell lysate

    Predicted band size : 51 kDa

Anti-alpha 1 Glycine Receptor antibody (ab26134)参考文献

ab26134 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry regarding our antibody to alpha 1 glycine receptor. To my knowledge, there is no experimental data on whether this antibody will also recognise alpha2 glysine receptor. I have done a BLAST sequence alignment analogy search, a...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"