概述

描述

  • 性质Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab48073 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • Alpha E-catenin
    • Cadherin associated protein
    • Cadherin associated protein 102kDa
    • Cadherin-associated protein
    • CAP 102
    • CAP102
    • Catenin (cadherin associated protein) alpha 1 102kDa
    • Catenin (cadherin associated protein), alpha 1, 102kDa
    • Catenin alpha 1
    • Catenin alpha-1
    • CTNA1_HUMAN
    • CTNNA 1
    • Ctnna1
    • FLJ36832
    • FLJ52416
    • NY REN 13 antigen
    • OTTHUMP00000224141
    • OTTHUMP00000224147
    • Renal carcinoma antigen NY REN 13
    • Renal carcinoma antigen NY-REN-13
    see all
  • 功能Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
  • 组织特异性Expressed ubiquitously in normal tissues.
  • 序列相似性Belongs to the vinculin/alpha-catenin family.
  • 翻译后修饰Sumoylated.
  • 细胞定位Cell membrane and Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.
  • Information by UniProt

alpha 1 Catenin peptide (ab48073)参考文献

ab48073 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab48073.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"