Anti-alpha 1 Catenin抗体(ab48034)

概述

  • 产品名称Anti-alpha 1 Catenin抗体
    参阅全部 alpha 1 Catenin 一抗
  • 描述
    山羊多克隆抗体to alpha 1 Catenin
  • 特异性This antibody is specific for alpha 1 Catenin
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Xenopus laevis, Chimpanzee, Cynomolgus Monkey, Macaque Monkey
  • 免疫原

    Synthetic peptide:

    KREKQDETQTKIK

    , corresponding to internal sequence amino acids 872/884 of Human alpha 1 Catenin

  • 阳性对照
    • Human Colon and Human Skin lysates

性能

应用

Our Abpromise guarantee covers the use of ab48034 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 100 kDa).
IHC-P Use a concentration of 3 - 6 µg/ml.

靶标

  • 功能Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
  • 组织特异性Expressed ubiquitously in normal tissues.
  • 序列相似性Belongs to the vinculin/alpha-catenin family.
  • 翻译后修饰Sumoylated.
  • 细胞定位Cell membrane and Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha E-catenin antibody
    • Cadherin associated protein 102kDa antibody
    • Cadherin associated protein antibody
    • Cadherin-associated protein antibody
    • CAP 102 antibody
    • CAP102 antibody
    • Catenin (cadherin associated protein) alpha 1 102kDa antibody
    • Catenin (cadherin associated protein), alpha 1, 102kDa antibody
    • Catenin alpha 1 antibody
    • Catenin alpha-1 antibody
    • CTNA1_HUMAN antibody
    • CTNNA 1 antibody
    • Ctnna1 antibody
    • FLJ36832 antibody
    • FLJ52416 antibody
    • NY REN 13 antigen antibody
    • OTTHUMP00000224141 antibody
    • OTTHUMP00000224147 antibody
    • Renal carcinoma antigen NY REN 13 antibody
    • Renal carcinoma antigen NY-REN-13 antibody
    see all

Anti-alpha 1 Catenin antibody 图像

  • Anti-alpha 1 Catenin antibody (ab48034) at 1 µg/ml + Human Colon lysate (35µg protein in RIPA buffer).

    Predicted band size : 100 kDa
    Observed band size : 100 kDa
  • ab48034 at 3.8 µg/ml staining alpha 1 catenin in Human prostate tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-alpha 1 Catenin antibody (ab48034)参考文献

ab48034 has not yet been referenced specifically in any publications.

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