Anti-alpha 1 Antichymotrypsin抗体(ab88527)

概述

  • 产品名称Anti-alpha 1 Antichymotrypsin抗体
    参阅全部 alpha 1 Antichymotrypsin 一抗
  • 描述
    小鼠多克隆抗体to alpha 1 Antichymotrypsin
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human alpha 1 Antichymotrypsin protein (NP_001076.2).

  • 阳性对照
    • WB: HeLa cell lysate and alpha 1 Antichymotrypsin transfected 293T cell lysate IF: HeLa cell

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab88527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
  • 组织特异性Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
  • 疾病相关Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
  • 序列相似性Belongs to the serpin family.
  • 结构域The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • SERPINA3 antibody
    • AACT antibody
    • AACT_HUMAN antibody
    • ACT antibody
    • Alpha-1-antichymotrypsin His-Pro-less antibody
    • Antichymotrypsin antibody
    • Cell growth inhibiting gene 24/25 protein antibody
    • Cell growth-inhibiting gene 24/25 protein antibody
    • GIG24 antibody
    • GIG25 antibody
    • Growth inhibiting protein 24 antibody
    • Growth inhibiting protein 25 antibody
    • MGC88254 antibody
    • Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3 antibody
    • Serine (or cysteine) proteinase inhibitor clade A member 3 antibody
    • Serine proteinase inhibitor clade A member 3 antibody
    • Serpin A3 antibody
    • Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3 antibody
    • SERPINA3 antibody
    see all

Anti-alpha 1 Antichymotrypsin antibody 图像

  • Anti-alpha 1 Antichymotrypsin antibody (ab88527) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 48 kDa
    Observed band size : 48 kDa
  • All lanes : Anti-alpha 1 Antichymotrypsin antibody (ab88527) at 1 µg/ml

    Lane 1 : alpha 1 Antichymotrypsin transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 47 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.
  • ab88527 at 10 µg/ml staining alpha 1 Antichymotrypsin in paraformaldehyde fixed, permeabilised HeLa cells, by immunofluorescence.

Anti-alpha 1 Antichymotrypsin antibody (ab88527)参考文献

ab88527 has not yet been referenced specifically in any publications.

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