概述

  • 产品名称Anti-ALOXE3抗体
    参阅全部 ALOXE3 一抗
  • 描述
    兔多克隆抗体to ALOXE3
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant Human ALOXE3.

  • 阳性对照
    • Human fetal lung lysate, Human fetal skin tissue

性能

应用

Our Abpromise guarantee covers the use of ab118470 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 81 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
  • 组织特异性Predominantly expressed in skin.
  • 通路Lipid metabolism; leukotriene D4 biosynthesis.
  • 疾病相关Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
  • 序列相似性Belongs to the lipoxygenase family.
    Contains 1 lipoxygenase domain.
    Contains 1 PLAT domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALOXE3 antibody
    • Arachidonate lipoxygenase 3 antibody
    • e LOX 3 antibody
    • E LOX antibody
    • e-LOX-3 antibody
    • eLOX3 antibody
    • Epidermal lipoxygenase antibody
    • Epidermis-type lipoxygenase 3 antibody
    • Lipoxygenase 3 antibody
    • LOXE3_HUMAN antibody
    see all

Anti-ALOXE3 antibody 图像

  • Anti-ALOXE3 antibody (ab118470) at 1/500 dilution + Human fetal lung lysate

    Predicted band size : 81 kDa
  • Staining of Human ALOXE3 in a Formalin/PFA-fixed paraffin-embedded section of Human fetal skin using ab118470 at a dilution of 1/100.

Anti-ALOXE3 antibody (ab118470)参考文献

ab118470 has not yet been referenced specifically in any publications.

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