Anti-e-LOX-3抗体(ab118470)
Key features and details
- Rabbit polyclonal to e-LOX-3
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-e-LOX-3抗体 -
描述
兔多克隆抗体to e-LOX-3 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant fragment corresponding to Human e-LOX-3.
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阳性对照
- Human fetal lung lysate, Human fetal skin tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute in 200µl Steriled Distilled Water -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab118470于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 81 kDa.
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IHC-P |
1/100 - 1/500.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 81 kDa. |
IHC-P
1/100 - 1/500. |
靶标
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功能
Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. -
组织特异性
Predominantly expressed in skin. -
通路
Lipid metabolism; leukotriene D4 biosynthesis. -
疾病相关
Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. -
序列相似性
Belongs to the lipoxygenase family.
Contains 1 lipoxygenase domain.
Contains 1 PLAT domain. - Information by UniProt
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数据库链接
- Entrez Gene: 59344 Human
- Entrez Gene: 23801 Mouse
- Entrez Gene: 287424 Rat
- Omim: 607206 Human
- SwissProt: Q9BYJ1 Human
- SwissProt: Q9WV07 Mouse
- Unigene: 232770 Human
- Unigene: 41989 Mouse
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别名
- ALOXE3 antibody
- Arachidonate lipoxygenase 3 antibody
- e LOX 3 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab118470 被引用在 3 文献中.
- Gao MM et al. The ALOXE3 gene variants from patients with Dravet syndrome decrease gene expression and enzyme activity. Brain Res Bull 170:81-89 (2021). PubMed: 33581311
- Tang HL et al. Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility. Cell Mol Neurobiol N/A:N/A (2020). PubMed: 33058074
- Xia Y et al. Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo. Cell Death Dis 11:988 (2020). PubMed: 33203867