概述

  • 产品名称
  • 描述
    兔多克隆抗体to ALMS1
  • 经测试应用
    适用于: ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 1200-1250 of human ALMS1 (EAW99731.1).

  • 阳性对照
    • HeLa Cells.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab84892 was affinity purified using an epitope specific to ALMS1 immobilized on solid support.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
  • 应用说明
    ICC/IF: 1/100 - 1/500. Formaldehyde fixation and permeabilization with Triton-X 100 is recommended.

    Acetone fixation is not recommended.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Possible role in intracellular trafficking.
    • 组织特异性
      Expressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).
    • 疾病相关
      Defects in ALMS1 are the cause of Alstrom syndrome (ALMS) [MIM:203800]. Alstrom syndrome is a rare autosomal recessive disorder characterized by progressive cone-rod retinal dystrophy, neurosensory hearing loss, early childhood obesity and type 2 diabetes mellitus. Dilated cardiomyopathy, acanthosis nigricans, male hypogonadism, hypothyroidism, developmental delay and hepatic dysfunction can also be associated with the syndrome.
    • 发展阶段
      Widely expressed in fetal tissues. Detected in fetal pancreas, skeletal muscle, liver, kidney and brain (at protein level). Expressed in fetal aorta and brain.
    • 翻译后修饰
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位
      Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > spindle pole. Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Alms1 antibody
      • ALMS1_HUMAN antibody
      • ALSS antibody
      • Alstrom syndrome 1 antibody
      • Alstrom syndrome protein 1 antibody
      see all

    Anti-ALMS1 antibody 图像

    • ab84892, at a 1/250 dilution, staining ALMS1 in NBF fixed asynchronous HeLa cells by Immunocytochemistry.
      Detection by Red fluorescent goat anti-rabbit IgG highly cross adsorbed antibody used at a dilution of 1/100.

    Anti-ALMS1 antibody (ab84892)参考文献

    This product has been referenced in:
    • Chen JH  et al. Truncation of POC1A associated with short stature and extreme insulin resistance. J Mol Endocrinol 55:147-58 (2015). ICC/IF ; Human . Read more (PubMed: 26336158) »

    See 1 Publication for this product

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