• 产品名称Anti-ALMS1抗体
    参阅全部 ALMS1 一抗
  • 描述
    山羊多克隆抗体to ALMS1
  • 特异性The C terminus of ALMS 1 shares an 8 amino acid stretch with two other human proteins: hypothetical protein (XP_169104) and ERAL1 (NP_005693). However, this stretch is located internally in these two proteins and so will most likely not cross-react with this antibody. The N terminus was not chosen as the peptide is expected to cyclise during synthesis. ALMS1 protein has got a molecular weight of approximately 460kD. ab4306 results in a WB band of the right size, confirming that this antibody recognises the right protein.
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide: RVTNQLLGRKVPWD, corresponding to C terminal amino acids 4145-4167 of Human ALMS1.

  • 常规说明GenBank Accession Number – NP_055935. LocusLink ID - 7840 (human); 236266 (mouse).


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域



Our Abpromise guarantee covers the use of ab4306 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200. Detects a band of approximately 460 kDa (predicted molecular weight: 460 kDa).Can be blocked with Human ALMS1 peptide (ab23023).
IHC-P Use a concentration of 1 - 3 µg/ml.


  • 功能Possible role in intracellular trafficking.
  • 组织特异性Expressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).
  • 疾病相关Defects in ALMS1 are the cause of Alstrom syndrome (ALMS) [MIM:203800]. Alstrom syndrome is a rare autosomal recessive disorder characterized by progressive cone-rod retinal dystrophy, neurosensory hearing loss, early childhood obesity and type 2 diabetes mellitus. Dilated cardiomyopathy, acanthosis nigricans, male hypogonadism, hypothyroidism, developmental delay and hepatic dysfunction can also be associated with the syndrome.
  • 发展阶段Widely expressed in fetal tissues. Detected in fetal pancreas, skeletal muscle, liver, kidney and brain (at protein level). Expressed in fetal aorta and brain.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > spindle pole. Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alms1 antibody
    • ALMS1_HUMAN antibody
    • ALSS antibody
    • Alstrom syndrome 1 antibody
    • Alstrom syndrome protein 1 antibody
    see all

Anti-ALMS1 antibody 图像

  • Predicted band size : 460 kDa

    20 µg of Hela extract were run on a Tris Acetate NuPage 3-8% gel and probed with a 1:200 dilution of the ab4306 antibody.

    The 460kD band represents ALMS1.
  • ab4306 (2µg/ml) staining of paraffin embedded Human Testis.

Anti-ALMS1 antibody (ab4306)参考文献

ab4306 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 100 µg
Gel Running Conditions Reduced Denaturing (6%)
Sample Rat Tissue lysate - whole (kidney)
Specification kidney
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 27°C


Verified customer

提交于 Oct 29 2014

Thank you for your enquiry. All the information that we have regarding this antibody is located on the online datasheet. So far, it has been tested in ELISA ( peptide ELISA (antibody detection limit dilution >1 / 32000) and no signal obtained yet in We...

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