概述

  • 产品名称Anti-ALG8抗体
    参阅全部 ALG8 一抗
  • 描述
    小鼠单克隆抗体to ALG8
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: NQLPQVFSRL FPFKRGLCHA YWAPNFWALY NALDKVLSVI GLKLKFLDPN NIPKASMTSG LVQQFQHTVL PSVTP, corresponding to amino acids 260-335 of Human ALG8

性能

应用

Our Abpromise guarantee covers the use of ab57715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
    • 通路Protein modification; protein glycosylation.
    • 疾病相关Defects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H) [MIM:608104]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
    • 序列相似性Belongs to the ALG6/ALG8 glucosyltransferase family.
    • 细胞定位Endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 3-glucosyltransferase antibody
      • AI447372 antibody
      • ALG 8 antibody
      • ALG8 alpha-1,3-glucosyltransferase antibody
      • alg8 antibody
      • ALG8_HUMAN antibody
      • Asparagine linked glycosylation 8 alpha 1,3 glucosyltransferase homolog antibody
      • Asparagine linked glycosylation 8 homolog yeast, alpha 1,3 glucosyltransferase antibody
      • Asparagine linked glycosylation 8 homolog S. cerevisiae, alpha 1,3 glucosyltransferase antibody
      • Asparagine-linked glycosylation protein 8 homolog antibody
      • CDG1H antibody
      • Dolichyl P Glc Glc1Man9GlcNAc2 PP dolichyl glucosyltransferase antibody
      • Dolichyl P glucose Glc1Man9GlcNAc2 PP dolichyl alpha 1,3 glucosyltransferase antibody
      • Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase antibody
      • Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase antibody
      • Gm1089 antibody
      • HUSSY 02 antibody
      • MGC2840 antibody
      • MGC74399 antibody
      • Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha 1,3 glucosyltransferase antibody
      • Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1 antibody
      see all

    Anti-ALG8 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57715 ALG8 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    Anti-ALG8 antibody (ab57715)参考文献

    ab57715 has not yet been referenced specifically in any publications.

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