概述

  • 产品名称
  • 描述
    小鼠多克隆抗体to ALG2
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human ALG2 protein (NP_149078.1, aa 1-416)

  • 阳性对照
    • ALG2 transfected 293T lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab69261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).

靶标

  • 功能
    Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
  • 通路
    Protein modification; protein glycosylation.
  • 疾病相关
    Defects in ALG2 are the cause of congenital disorder of glycosylation type 1I (CDG1I) [MIM:607906]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • 序列相似性
    Belongs to the glycosyltransferase 1 family.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3-mannosyltransferase ALG2 antibody
    • ALG2 alpha-1,3/1,6-mannosyltransferase antibody
    • ALG2 antibody
    • ALG2_HUMAN antibody
    • Alpha 1,3 mannosyltransferase ALG2 antibody
    • Alpha-1 antibody
    • Asparagine linked glycosylation protein 2 antibody
    • Asparagine-linked glycosylation protein 2 homolog antibody
    • CDGIi antibody
    • FLJ14511 antibody
    • GDP Man:Man(1)GlcNAc(2) PP dolichol mannosyltransferase antibody
    • GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase antibody
    • hALPG2 antibody
    • NET38 antibody
    • OTTHUMP00000021785 antibody
    • OTTHUMP00000123474 antibody
    • RP11-13B9.1 antibody
    see all

Anti-ALG2 antibody 图像

  • All lanes : Anti-ALG2 antibody (ab69261) at 1/500 dilution

    Lane 1 : ALG2 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 48 kDa
    Observed band size : 48 kDa

实验方案

Anti-ALG2 antibody (ab69261)参考文献

ab69261 has not yet been referenced specifically in any publications.

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