概述

  • 产品名称Anti-ALG1抗体
    参阅全部 ALG1 一抗
  • 描述
    兔多克隆抗体to ALG1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cat, Saccharomyces cerevisiae
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 38-87 (VVLGDVGRSP RMQYHALSLA MHGFSVTLLG FCNSKPHDEL LQNNRIQIVG) of Human ALG1 (NP_061982).

  • 阳性对照
    • NTERA2 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab81134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 52 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/62500.

靶标

  • 功能Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
  • 通路Protein modification; protein glycosylation.
  • 疾病相关Defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K) [MIM:608540]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • 序列相似性Belongs to the glycosyltransferase 1 family.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
    see all
  • 别名
    • 4-mannosyltransferase antibody
    • Alg1 antibody
    • ALG1_HUMAN antibody
    • asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) antibody
    • asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) antibody
    • Asparagine-linked glycosylation protein 1 homolog antibody
    • Beta 1 4 mannosyltransferase antibody
    • Beta-1 antibody
    • CDG1K antibody
    • Chitobiosyldiphosphodolichol beta-mannosyltransferase antibody
    • GDP Man GlcNAc2 PP dolichol mannosyltransferase antibody
    • GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase antibody
    • GDP-mannose-dolichol diphosphochitobiose mannosyltransferase antibody
    • Hmat-1 antibody
    • HMAT1 antibody
    • HMT 1 antibody
    • HMT1 antibody
    • Mannosyltransferase 1 antibody
    • Mannosyltransferase-1 antibody
    • MT 1 antibody
    • MT-1 antibody
    • MT1 antibody
    see all

Anti-ALG1 antibody 图像

  • Anti-ALG1 antibody (ab81134) at 1 µg/ml (in 5% skim milk / PBS buffer) + NTERA2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 52 kDa
    Observed band size : 52 kDa

Anti-ALG1 antibody (ab81134)参考文献

ab81134 has not yet been referenced specifically in any publications.

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