概述

  • 产品名称Anti-ALAD抗体
    参阅全部 ALAD 一抗
  • 描述
    小鼠多克隆抗体to ALAD
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human ALAD, amino acids 1-339 (NP_000022.2)

  • 阳性对照
    • Human liver tissue lysate, ALAD transfected 293T cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab88875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa.

靶标

  • 功能Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
  • 通路Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
  • 疾病相关Defects in ALAD are the cause of acute hepatic porphyria (AHP) [MIM:612740]. AHP is a form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. AHP is characterized by attacks of gastrointestinal disturbances, abdominal colic, paralysis, and peripheral neuropathy. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors.
  • 序列相似性Belongs to the ALADH family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALAD antibody
    • ALADH antibody
    • ALADR antibody
    • Aminolevulinate dehydratase antibody
    • Aminolevulinate, delta, dehydratase antibody
    • Delta aminolevulinic acid dehydratase antibody
    • Delta-aminolevulinic acid dehydratase antibody
    • HEM2_HUMAN antibody
    • Lv antibody
    • MGC5057 antibody
    • OTTMUSP00000009376 antibody
    • OTTMUSP00000009377 antibody
    • PBGS antibody
    • Porphobilinogen synthase antibody
    • RP11-10I9.1 antibody
    • RP24-189G18.9 antibody
    see all

Anti-ALAD antibody 图像

  • Anti-ALAD antibody (ab88875) at 1 µg/ml + human liver tissue lysate at 50 µg

    Predicted band size : 37 kDa
    Observed band size : 37 kDa
    Additional bands at : 20 kDa. We are unsure as to the identity of these extra bands.
  • All lanes : Anti-ALAD antibody (ab88875) at 1 µg/ml

    Lane 1 : ALAD transfected 293T cell lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 37 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)

Anti-ALAD antibody (ab88875)参考文献

ab88875 has not yet been referenced specifically in any publications.

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