Anti-AKR1A1抗体(ab125878)
Key features and details
- Rabbit polyclonal to AKR1A1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-AKR1A1抗体
参阅全部 AKR1A1 一抗 -
描述
兔多克隆抗体to AKR1A1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rat, Cow, Pig -
免疫原
Recombinant fragment, corresponding to amino acids 1 - 131 of Human AKR1A1 (P14550).
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阳性对照
- A549 whole cell lysate HepG2 whole cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab125878于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 37 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 37 kDa. |
靶标
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功能
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). -
组织特异性
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. -
序列相似性
Belongs to the aldo/keto reductase family. - Information by UniProt
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数据库链接
- Entrez Gene: 618607 Cow
- Entrez Gene: 10327 Human
- Entrez Gene: 396924 Pig
- Entrez Gene: 78959 Rat
- Omim: 103830 Human
- SwissProt: Q3ZCJ2 Cow
- SwissProt: P14550 Human
- SwissProt: P50578 Pig
see all -
别名
- AK1A1_HUMAN antibody
- Akr1a1 antibody
- Alcohol dehydrogenase [NADP+] antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab125878 被引用在 1 文献中.
- Mishra P et al. ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming. J Clin Invest 128:323-340 (2018). PubMed: 29202474