概述

  • 产品名称Anti-AKR1A1抗体
    参阅全部 AKR1A1 一抗
  • 描述
    山羊多克隆抗体to AKR1A1
  • 经测试应用适用于: IHC-P, ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide: DAGHPLYPFNDPY, corresponding to amino acids 312-324 of Human AKR1A1.

  • 阳性对照
    • Human Placenta and Liver lysates.

性能

应用

Our Abpromise guarantee covers the use of ab11802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 2 - 3 µg/ml.
ELISA 1/16000. This application has only been tested against the recombinant protein.
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 37 kDa.Can be blocked with Human AKR1A1 peptide (ab23210). Approx 37-40kDa band observed in Human Placenta and Liver lysates.

靶标

  • 功能Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
  • 组织特异性Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • 序列相似性Belongs to the aldo/keto reductase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AK1A1_HUMAN antibody
    • Akr1a1 antibody
    • Alcohol dehydrogenase [NADP+] antibody
    • Alcohol dehydrogenase antibody
    • Aldehyde reductase antibody
    • Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody
    • Aldo-keto reductase family 1 member A1 antibody
    • ALDR1 antibody
    • ALR antibody
    • ARM antibody
    • DD3 antibody
    • MGC12529 antibody
    • MGC1380 antibody
    see all

Anti-AKR1A1 antibody 图像

  • Anti-AKR1A1 antibody (ab11802) at 0.1 µg/ml + Human Liver lysate (in RIPA buffer) at 35 µg

    Predicted band size : 37 kDa
    Observed band size : 37 kDa
  • ab11802 at 2.5µg/ml, staining AKR1A1 in Human Kidney sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with pH 6 citrate buffer was performed, and AP-staining was used.

Anti-AKR1A1 antibody (ab11802)参考文献

This product has been referenced in:
  • Singh S  et al. SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity. Int J Biochem Cell Biol 42:1105-14 (2010). Read more (PubMed: 20097305) »
  • Diggle CP  et al. Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem 57:763-74 (2009). Read more (PubMed: 19365088) »

See all 2 Publications for this product

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