概述

  • 产品名称Anti-AKAP13抗体
    参阅全部 AKAP13 一抗
  • 描述
    兔多克隆抗体to AKAP13
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Guinea pig, Chimpanzee, Gorilla, Opossum, Orangutan, Bat, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residues 1850 and 1900 of Human AKAP13 (NP_009131.2).

  • 阳性对照
    • HeLa whole cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab99318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.
    • 组织特异性Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver.
    • 序列相似性Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 phorbol-ester/DAG-type zinc finger.
    • 结构域Both the DH and PH domains are required for transforming activity.
    • 细胞定位Cytoplasm; Cytoplasm. Nucleus and Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A kinase (PRKA) anchor protein 13 antibody
      • A kinase anchor protein 13 antibody
      • A kinase anchoring protein antibody
      • A-kinase anchor protein 13 antibody
      • AKAP 13 antibody
      • AKAP Lbc antibody
      • AKAP-13 antibody
      • AKAP-Lbc antibody
      • AKAP13 antibody
      • AKP13_HUMAN antibody
      • ARHGEF13 antibody
      • Breast cancer nuclear receptor binding auxiliary protein antibody
      • Breast cancer nuclear receptor-binding auxiliary protein antibody
      • BRX antibody
      • c lbc antibody
      • FLJ11952 antibody
      • FLJ43341 antibody
      • Guanine nucleotide exchange factor Lbc antibody
      • HA 3 antibody
      • HA3 antibody
      • Ht 31 antibody
      • Ht31 antibody
      • Human thyroid anchoring protein 31 antibody
      • Human thyroid-anchoring protein 31 antibody
      • LBC antibody
      • LBC oncogene antibody
      • Lymphoid blast crisis oncogene antibody
      • Non oncogenic Rho GTPase specific GTP exchange factor antibody
      • Non-oncogenic Rho GTPase-specific GTP exchange factor antibody
      • p47 antibody
      • Protein kinase A anchoring protein 13 antibody
      • Protein kinase A-anchoring protein 13 antibody
      • PROTO LB antibody
      • PROTO LBC antibody
      see all

    Anti-AKAP13 antibody 图像

    • Detection of AKAP13 by Western Blot of Immunprecipitate.
      An antibody to AKAP13 at 0.1 µg/ml staining AKAP13 in HeLa whole cell lysate immunoprecipitated using ab99318 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.

    Anti-AKAP13 antibody (ab99318)参考文献

    ab99318 has not yet been referenced specifically in any publications.

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