Anti-AKAP12抗体(ab9698)

概述

• 产品名称Anti-AKAP12抗体
  参阅全部 AKAP12 一抗
• 描述
  山羊多克隆抗体to AKAP12
• 经测试应用适用于: WBmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide:

  C-KQERESAKSELTES

  , corresponding to C terminal amino acids 1769-1782 of Human AKAP12(Peptide available as ab23159.)
  Run BLAST with Run BLAST with
• 阳性对照
  • Jurkat and HeLa cell lysates

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
• Concentration information loading...
• 纯度IgG fraction
• 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Phosphatases

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • PKC

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • PKA

  • Signal Transduction
  • Adapters
  • Cytoplasmic

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Other

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Kinases/Phosphatases
  • Other

相关产品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
• Immunizing Peptide (Blocking)
  • Human AKAP12 peptide (ab23159)
• Positive Controls
  • Jurkat whole cell lysate (ab7899)

应用

靶标

• 功能Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
• 组织特异性Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
• 序列相似性Contains 3 AKAP domains.
• 结构域Polybasic regions located between residues 266 and 557 are involved in binding PKC.
• 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
• 细胞定位Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. May be part of the cortical cytoskeleton.

• Target information above from: UniProt accession Q02952 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 9590 Human
  • Omim: 604698 Human
  • SwissProt: Q02952 Human
  • Unigene: 371240 Human
• 别名
  • A kinase (PRKA) anchor protein (gravin) 12 antibody
  • A kinase Anchor Protein 12 antibody
  • A kinase anchor protein 250kDa antibody

  • A-kinase anchor protein 12 antibody
  • A-kinase anchor protein 250 kDa antibody
  • AKA12_HUMAN antibody
  • AKAP 12 antibody
  • AKAP 250 antibody
  • AKAP-12 antibody
  • Akap12 antibody
  • AKAP250 antibody
  • DKFZp686M0430 antibody
  • DKFZp686O0331 antibody
  • FLJ20945 antibody
  • FLJ97621 antibody
  • Gercelin antibody
  • Gravin antibody
  • Kinase scaffold protein gravin antibody
  • Myasthenia gravis autoantigen antibody
  • Myasthenia gravis autoantigen gravin antibody
  • OTTHUMP00000017426 antibody
  • OTTHUMP00000017427 antibody
  • Src-Suppressed C Kinase Substrate antibody
  • Srcs5 antibody
  • SSeCKS antibody
  • Tsga12 antibody

  see all