概述

  • 产品名称
  • 描述
    山羊多克隆抗体to AKAP12
  • 特异性
    ab118365 is expected to recognize isoform 1 (NP_005091.2) only.
  • 种属反应性

    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    SPDTNGPKLTEEGD

    with a Cysteine residue linker, corresponding to internal sequence amino acids 1645-1658 of Mouse AKAP12 (NP_112462.1).

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab118365 is purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

  • 应用说明
    Is unsuitable for WB.
  • 靶标

    • 功能
      Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
    • 组织特异性
      Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
    • 序列相似性
      Contains 3 AKAP domains.
    • 结构域
      Polybasic regions located between residues 266 and 557 are involved in binding PKC.
    • 翻译后修饰
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位
      Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. May be part of the cortical cytoskeleton.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A kinase (PRKA) anchor protein (gravin) 12 antibody
      • A kinase Anchor Protein 12 antibody
      • A kinase anchor protein 250kDa antibody
      • A-kinase anchor protein 12 antibody
      • A-kinase anchor protein 250 kDa antibody
      • AKA12_HUMAN antibody
      • AKAP 12 antibody
      • AKAP 250 antibody
      • AKAP-12 antibody
      • Akap12 antibody
      • AKAP250 antibody
      • DKFZp686M0430 antibody
      • DKFZp686O0331 antibody
      • FLJ20945 antibody
      • FLJ97621 antibody
      • Gercelin antibody
      • Gravin antibody
      • Kinase scaffold protein gravin antibody
      • Myasthenia gravis autoantigen antibody
      • Myasthenia gravis autoantigen gravin antibody
      • OTTHUMP00000017426 antibody
      • OTTHUMP00000017427 antibody
      • Src-Suppressed C Kinase Substrate antibody
      • Srcs5 antibody
      • SSeCKS antibody
      • Tsga12 antibody
      see all

    文献

    ab118365 has not yet been referenced specifically in any publications.

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