概述

  • 产品名称
    Anti-AKAP11抗体
  • 描述
    兔多克隆抗体to AKAP11
  • 经测试应用
    适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 1190-1281 of Human AKAP11 (UniProt ID: Q9UKA4).

  • 阳性对照
    • Human kidney tissue

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab122529 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 4 µg/ml.
IHC-P 1/1000. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

靶标

  • 功能
    Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
  • 组织特异性
    Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.
  • 序列相似性
    Belongs to the AKAP110 family.
  • 结构域
    RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • 细胞定位
    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • A-kinase anchor protein 11 antibody
    • A-kinase anchor protein 220 kDa antibody
    • AKA11_HUMAN antibody
    • AKAP 220 antibody
    • AKAP-11 antibody
    • AKAP11 antibody
    • hAKAP220 antibody
    • PRKA11 antibody
    • Protein kinase A-anchoring protein 11 antibody
    see all

图片

  • Immunohistochemical staining of AKAP11 in paraffin embedded Human kidney tissue by Immunohistochemistry, using ab122529 at a 1/1000 dilution. The image shows strong cytoplasmic positivity in cells in tubules.

文献

ab122529 has not yet been referenced specifically in any publications.

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