概述

  • 产品名称Anti-AKAP10抗体
    参阅全部 AKAP10 一抗
  • 描述
    兔多克隆抗体to AKAP10
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 600-662 (ESEPEPDVRK SKGSMFSQAM KKWVQGNTDE AQEELAWKIA KMIVSDIMQQ AQYDQPLEKS TKL) of Human AKAP10

  • 阳性对照
    • HeLa, HepG2 cells. OVCAR3 tissue, T(gastric CA) tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab97354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 74 kDa.
IHC-P 1/100 - 1/250.

靶标

  • 功能Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
  • 疾病相关Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:115080]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.
  • 序列相似性Contains 2 RGS domains.
  • 结构域RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • 细胞定位Mitochondrion. Membrane. Cytoplasm. Predominantly mitochondrial but also membrane associated and cytoplasmic.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1500031L16Rik antibody
    • A kinase (PRKA) anchor protein 10 antibody
    • A kinase anchor protein 10 antibody
    • A kinase anchor protein 10 mitochondrial antibody
    • A-kinase anchor protein 10 antibody
    • AKA10_HUMAN antibody
    • akap 10 antibody
    • AKAP-10 antibody
    • AKAP10 antibody
    • B130049N18Rik antibody
    • D AKAP 2 antibody
    • D-AKAP-2 antibody
    • dakap 2 antibody
    • dakap2 antibody
    • Dual specific A kinase anchoring protein 2 antibody
    • Dual specificity A kinase-anchoring protein 2 antibody
    • mgc9410 antibody
    • MGC9414| antibody
    • Mitochondrial A kinase PPKA anchor protein 10 antibody
    • mitochondrial antibody
    • prka 10 antibody
    • PRKA10 antibody
    • Protein A kinase anchoring protein 10 antibody
    • Protein A kinase anchoring protein 10 mitochondrial precursor antibody
    • Protein kinase A anchoring protein 10 antibody
    • Protein kinase A-anchoring protein 10 antibody
    see all

Anti-AKAP10 antibody 图像

  • Anti-AKAP10 antibody (ab97354) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 74 kDa
  • Immunohistochemical analysis of paraffin-embedded T(gastric CA), using AKAP10 antibody (ab97354) at 1/100 dilution.
  • Immunohistochemical analysis of paraffin-embedded OVCAR3, using AKAP10 antibody (ab97354) at 1/100 dilution.

Anti-AKAP10 antibody (ab97354)参考文献

ab97354 has not yet been referenced specifically in any publications.

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