概述

  • 产品名称Anti-AK2抗体
    参阅全部 AK2 一抗
  • 描述
    兔多克隆抗体to AK2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human AK2.
    Database link: NM_001625

  • 阳性对照
    • Human fetal kidney lysate and hepatocarcinoma tissue

应用

Our Abpromise guarantee covers the use of ab93856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    WB: 1/200 - 1/1000. Predicted molecular weight: 26 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.
    • 组织特异性Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
    • 疾病相关Defects in AK2 are the cause of reticular dysgenesis (RDYS) [MIM:267500]; also known as aleukocytosis. RDYS is the most severe form of inborn severe combined immunodeficiencies (SCID) and is characterized by absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immune functions, leading to fatal septicemia within days after birth. In bone marrow of individuals with reticular dysgenesis, myeloid differentiation is blocked at the promyelocytic stage, whereas erythro- and megakaryocytic maturation is generally normal.In addition, affected newborns have bilateral sensorineural deafness. Defects may be due to its absence in leukocytes and inner ear, in which its absence can not be compensated by AK1.
    • 序列相似性Belongs to the adenylate kinase family. AK2 subfamily.
    • 细胞定位Mitochondrion intermembrane space.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Adenylate kinase 2 antibody
      • adenylate kinase 2, mitochondrial antibody
      • Adenylate kinase isoenzyme 2 antibody
      • ADK2 antibody
      • AK 2 antibody
      • ak2 antibody
      • ATP AMP transphosphorylase antibody
      • ATP-AMP transphosphorylase 2 antibody
      • EC 2.7.4.3 antibody
      • KAD2_HUMAN antibody
      • mitochondrial antibody
      see all

    Anti-AK2 antibody 图像

    • ab93856, at a 1/100 dilution, showing cytoplasmic staining of Human AK2 in hepatocarcinoma tissue, by Immunohistochemistry, (Formalin/PFA-fixed paraffin-embedded).
    • Anti-AK2 antibody (ab93856) at 1/500 dilution + Fetal kidney lysate

      Predicted band size : 26 kDa

    Anti-AK2 antibody (ab93856)参考文献

    ab93856 has not yet been referenced specifically in any publications.

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