概述

  • 产品名称Anti-AIMP2/p38抗体
    参阅全部 AIMP2/p38 一抗
  • 描述
    小鼠多克隆抗体to AIMP2/p38
  • 特异性This antibody is reactive against mammalian transfected lysate.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length AIMP2/p38 protein (Human)

  • 阳性对照
    • AIMP2/p38 transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab67471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/1000. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).
    Detection Antibody Pair.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
    • 序列相似性Contains 1 GST C-terminal domain.
    • 翻译后修饰Phosphorylated on serine residues in response to UV irradiation.
      Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
    • 细胞定位Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Aimp2 antibody
      • AIMP2_HUMAN antibody
      • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
      • Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody
      • ARS interacting multi functional protein 2 antibody
      • JTV 1 antibody
      • JTV 1 protein antibody
      • JTV1 antibody
      • JTV1 gene antibody
      • Multisynthase complex auxiliary component p38 antibody
      • Multisynthetase complex auxiliary component p38 antibody
      • P38 antibody
      • PRO0992 antibody
      • Protein JTV 1 antibody
      • Protein JTV-1 antibody
      • tRNA SYNTHETASE COFACTOR p38 antibody
      see all

    Anti-AIMP2/p38 antibody 图像

    • All lanes : Anti-AIMP2/p38 antibody (ab67471) at 1/500 dilution

      Lane 1 : AIMP2/p38 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 35 kDa
      Observed band size : 35 kDa

    Anti-AIMP2/p38 antibody (ab67471)参考文献

    ab67471 has not yet been referenced specifically in any publications.

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