概述

  • 产品名称Anti-AIMP2/p38抗体
    参阅全部 AIMP2/p38 一抗
  • 描述
    兔多克隆抗体to AIMP2/p38
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide from internal sequence amino acids of Human AIMP2/p38.

  • 阳性对照
    • Rat liver, lung, kidney, and brain lysates; Jurkat, CEM, HUT and U93T whole cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab125218 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. The detection limit for ab125218 is 1ng/lane under non-reducing and reducing conditions.
IHC-P Use a concentration of 1 µg/ml.

靶标

  • 功能Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
  • 序列相似性Contains 1 GST C-terminal domain.
  • 翻译后修饰Phosphorylated on serine residues in response to UV irradiation.
    Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • 细胞定位Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aimp2 antibody
    • AIMP2_HUMAN antibody
    • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
    • Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody
    • ARS interacting multi functional protein 2 antibody
    • JTV 1 antibody
    • JTV 1 protein antibody
    • JTV1 antibody
    • JTV1 gene antibody
    • Multisynthase complex auxiliary component p38 antibody
    • Multisynthetase complex auxiliary component p38 antibody
    • P38 antibody
    • PRO0992 antibody
    • Protein JTV 1 antibody
    • Protein JTV-1 antibody
    • tRNA SYNTHETASE COFACTOR p38 antibody
    see all

Anti-AIMP2/p38 antibody 图像

  • All lanes : Anti-AIMP2/p38 antibody (ab125218) at 1 µg/ml

    Lane 1 : Rat liver tissue lysate
    Lane 2 : Rat lung tissue lysate
    Lane 3 : Rat kidney tissue lysate
    Lane 4 : Rat brain tissue lysate
    Lane 5 : Rabbit IgG (55kDa)
    Lane 6 : Jurkat whole cell lysate
    Lane 7 : CEM whole cell lysate
    Lane 8 : HUT whole cell lysate
    Lane 9 : U93T whole cell lysate


    Predicted band size : 35 kDa
  • ab125218 at 1ug/ml in paraffin embedded Human tumour tissue by immunohistochemistry.

Anti-AIMP2/p38 antibody (ab125218)参考文献

ab125218 has not yet been referenced specifically in any publications.

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