概述

  • 产品名称Anti-AIMP2/p38抗体
    参阅全部 AIMP2/p38 一抗
  • 描述
    兔多克隆抗体to AIMP2/p38
  • 经测试应用适用于: IP, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 2-172 of Human AIMP2/p38 (AAH02853).

  • 阳性对照
    • HCT116, HeLa and A549 cell lines; and HepG2 whole cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab101840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration. PubMed: 24312579
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

靶标

  • 功能Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
  • 序列相似性Contains 1 GST C-terminal domain.
  • 翻译后修饰Phosphorylated on serine residues in response to UV irradiation.
    Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • 细胞定位Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aimp2 antibody
    • AIMP2_HUMAN antibody
    • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
    • Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody
    • ARS interacting multi functional protein 2 antibody
    • JTV 1 antibody
    • JTV 1 protein antibody
    • JTV1 antibody
    • JTV1 gene antibody
    • Multisynthase complex auxiliary component p38 antibody
    • Multisynthetase complex auxiliary component p38 antibody
    • P38 antibody
    • PRO0992 antibody
    • Protein JTV 1 antibody
    • Protein JTV-1 antibody
    • tRNA SYNTHETASE COFACTOR p38 antibody
    see all

Anti-AIMP2/p38 antibody 图像

  • Anti-AIMP2/p38 antibody (ab101840) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 35 kDa
    10% SDS PAGE

Anti-AIMP2/p38 antibody (ab101840)参考文献

This product has been referenced in:
  • Park SJ  et al. Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography. PLoS One 10:e0142253 (2015). WB ; Human . Read more (PubMed: 26544075) »
  • Kim K  et al. Reinvestigation of aminoacyl-TRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. PLoS One 8:e81734 (2013). WB, IP ; Human . Read more (PubMed: 24312579) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab101840.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"