功能Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
序列相似性Contains 1 GST C-terminal domain.
翻译后修饰Phosphorylated on serine residues in response to UV irradiation. Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
细胞定位Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Anti-AIMP2/p38 antibody (ab101840) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size : 35 kDa 10% SDS PAGE
Anti-AIMP2/p38 antibody (ab101840)参考文献
This product has been referenced in:
Park SJ et al. Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography. PLoS One10:e0142253 (2015).
Read more (PubMed: 26544075) »
Kim K et al. Reinvestigation of aminoacyl-TRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. PLoS One8:e81734 (2013).
Read more (PubMed: 24312579) »