概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab7871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

常规信息

  • 别名
    • AIFM1
    • AIFM1_HUMAN
    • Apoptosis inducing factor
    • Apoptosis inducing factor 1, mitochondrial
    • Apoptosis inducing factor, mitochondrion associated, 1
    • Apoptosis-inducing factor 1
    • CMTX4
    • COWCK
    • COXPD6
    • Harlequin
    • Hq
    • mAIF
    • MGC111425
    • MGC5706
    • mitochondrial
    • Neuropathy, axonal motor-sensory, with deafness and mental retardation
    • neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome)
    • PDCD 8
    • PDCD8
    • Programmed cell death 8
    • Programmed cell death 8 (apoptosis inducing factor)
    • Programmed cell death 8 isoform 1
    • Programmed cell death 8 isoform 2
    • Programmed cell death 8 isoform 3
    • Programmed cell death protein 8
    • Programmed cell death protein 8 mitochondrial
    • Programmed cell death protein 8 mitochondrial precursor
    • Striatal apoptosis inducing factor
    see all
  • 功能Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
  • 疾病相关Defects in AIFM1 are the cause of combined oxidative phosphorylation deficiency type 6 (COXPD6) [MIM:300816]. It is a mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, areflexia, muscle weakness and wasting.
  • 序列相似性Belongs to the FAD-dependent oxidoreductase family.
  • 翻译后修饰Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner.
  • 细胞定位Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
  • Information by UniProt

AIF peptide (ab7871)参考文献

ab7871 has not yet been referenced specifically in any publications.

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