Anti-AICDA抗体(ab93596)
Key features and details
- Rabbit polyclonal to AICDA
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-AICDA抗体
参阅全部 AICDA 一抗 -
描述
兔多克隆抗体to AICDA -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
A 16 amino acid peptide from near N terminal residues of Human AICDA
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
Affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab93596于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/100 - 1/500.
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说明 |
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IHC-P
1/100 - 1/500. |
靶标
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功能
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. -
组织特异性
Strongly expressed in lymph nodes and tonsils. -
疾病相关
Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers. -
序列相似性
Belongs to the cytidine and deoxycytidylate deaminase family. - Information by UniProt
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数据库链接
- Entrez Gene: 57379 Human
- Omim: 605257 Human
- SwissProt: Q9GZX7 Human
- Unigene: 149342 Human
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别名
- Activation induced cytidine deaminase antibody
- Activation induced deaminase antibody
- Activation-induced cytidine deaminase antibody
see all
图片
数据表及文件
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Datasheet download
文献 (2)
ab93596 被引用在 2 文献中.
- Fitzpatrick Z et al. Gut-educated IgA plasma cells defend the meningeal venous sinuses. Nature 587:472-476 (2020). PubMed: 33149302
- Wilson JJ et al. Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition. Cancer Biol Ther N/A:1-14 (2018). PubMed: 30183475