概述

  • 产品名称Anti-AICDA抗体
    参阅全部 AICDA 一抗
  • 描述
    山羊多克隆抗体to AICDA
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow, Dog
  • 免疫原

    Peptide with sequence

    RRKFLYQFKNVR

    -C, from the N terminus of human AICDA protein (NP_065712.1).

  • 阳性对照
    • Human tonsil lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Use at an assay dependent dilution. Detection limit dilution 1:1,000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 24 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
    • 组织特异性Strongly expressed in lymph nodes and tonsils.
    • 疾病相关Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
    • 序列相似性Belongs to the cytidine and deoxycytidylate deaminase family.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activation induced cytidine deaminase antibody
      • Activation induced deaminase antibody
      • Activation-induced cytidine deaminase antibody
      • AICDA antibody
      • AICDA_HUMAN antibody
      • AID antibody
      • ARP 2 antibody
      • ARP2 antibody
      • CDA 2 antibody
      • CDA2 antibody
      • Cytidine aminohydrolase antibody
      • HIGM2 antibody
      • Integrated into Burkitt's lymphoma cell line Ramos antibody
      see all

    Anti-AICDA antibody 图像

    • Anti-AICDA antibody (ab77401) at 0.3 µg/ml + Human tonsil lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 24 kDa
      Observed band size : 26 kDa (why is the actual band size different from the predicted?)


      Exposure time : 1 hour

    Anti-AICDA antibody (ab77401)参考文献

    ab77401 has not yet been referenced specifically in any publications.

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