概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
  • Concentration information loading...
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab2474 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 2.5 µg/ml.
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 45 kDa).Can be blocked with Human AIBZIP peptide (ab22911).

靶标

  • 功能Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.
  • 组织特异性According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
  • 序列相似性Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • 翻译后修饰N-glycosylated in the C-terminal region.
    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region.
  • 细胞定位Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. May also be located in Golgi apparatus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1700012K17Rik antibody
    • AIbZIP antibody
    • Androgen induced basic leucine zipper antibody
    • Androgen induced basic leucine zipper protein antibody
    • Androgen-induced basic leucine zipper protein antibody
    • ATCE1 antibody
    • Attaching to CRE like 1 antibody
    • Attaching to CRE-like 1 antibody
    • cAMP responsive element binding protein 1 antibody
    • cAMP responsive element binding protein 3 like 4 antibody
    • cAMP responsive element binding protein 4 antibody
    • cAMP responsive element-binding protein 3 like protein 4 antibody
    • cAMP-responsive element-binding protein 3-like protein 4 antibody
    • cAMP-responsive element-binding protein 4 antibody
    • CR3L4_HUMAN antibody
    • CREB 4 antibody
    • CREB-4 antibody
    • CREB3 antibody
    • CREB3L4 antibody
    • CREB4 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 4 antibody
    • Cyclic AMP responsive element binding protein 4 antibody
    • Cyclic AMP-responsive element-binding protein 4 antibody
    • hJAL antibody
    • JAL antibody
    • mJAL antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 4 antibody
    • Tisp40 antibody
    • Tisp40alpha antibody
    • Tisp40beta antibody
    • Transcript induced in spermiogenesis protein 40 antibody
    see all

Anti-AIBZIP antibody 图像

  • Anti-AIBZIP antibody (ab2474) at 0.5 µg/ml + Human placental lysates at 35 µg
    Developed using the ECL technique

    Predicted band size : 45 kDa
  • ab2474 at 2.5ug/ml staining AIBZIP in human prostate tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). The AP-staining procedure was used for detection.

Anti-AIBZIP antibody (ab2474)参考文献

ab2474 has not yet been referenced specifically in any publications.

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