Anti-AHRR抗体(ab108518)

概述

  • 产品名称Anti-AHRR抗体
    参阅全部 AHRR 一抗
  • 描述
    兔多克隆抗体to AHRR
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide from the N terminal region of Human AHRR.

  • 阳性对照
    • Human fetal testis tissue. Human fetal lung, testis and spleen lysates.

性能

  • 形式Lyophilised:Reconstitute with 200ul distilled H2O. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 1% BSA, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab108518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Predicted molecular weight: 76 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
  • 组织特异性Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • 细胞定位Cytoplasm. Nucleus. Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AHH antibody
    • AhR repressor antibody
    • AhRR antibody
    • AHRR_HUMAN antibody
    • aryl hydrocarbon hydroxylase regulator antibody
    • aryl hydrocarbon receptor regulator antibody
    • Aryl hydrocarbon receptor repressor antibody
    • Arylhydrocarbon receptor repressor antibody
    • bHLHe77 antibody
    • Class E basic helix-loop-helix protein 77 antibody
    • Dioxin receptor repressor antibody
    • KIAA1234 antibody
    • MGC167813 antibody
    • MGC176630 antibody
    • OTTHUMP00000221488 antibody
    • OTTHUMP00000221489 antibody
    see all

Anti-AHRR antibody 图像

  • All lanes : Anti-AHRR antibody (ab108518) at 1/1000 dilution

    Lane 1 : Fetal testis lysate
    Lane 2 : Fetal lung lysate
    Lane 3 : Fetal spleen lysate


    Predicted band size : 76 kDa
  • ab108518 at 1/100 dilution showing cytoplasmic and nuclear staining of AHRR in formalin-fixed, paraffin-embedded Human fetal testis by Immunohistochemistry.

Anti-AHRR antibody (ab108518)参考文献

ab108518 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your interest in ab108518. All of the information we currently have regarding this antibody is available on our online datasheet. At this time, no one has reported the use of this product to us in T-cells. However, we guarantee this ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"