概述

  • 产品名称Anti-AHI1抗体
    参阅全部 AHI1 一抗
  • 描述
    兔多克隆抗体to AHI1
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 25-75 of Human AHI1 according to NP_001128302.1.

  • 阳性对照
    • Whole cell lysate from HeLa cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH 7-8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab117815 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 组织特异性Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level).
    • 疾病相关Defects in AHI1 are the cause of Joubert syndrome type 3 (JBTS3) [MIM:608629]. JBTS is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. JBTS3 shows minimal extra central nervous system involvement and appears not to be associated with renal dysfunction.
    • 序列相似性Contains 1 SH3 domain.
      Contains 7 WD repeats.
    • 细胞定位Cytoplasm > cytoskeleton > cilium basal body. Cell junction > adherens junction.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Abelson helper integration site 1 antibody
      • Abelson helper integration site 1 protein homolog antibody
      • Abelson helper integration site antibody
      • AHI 1 antibody
      • AHI-1 antibody
      • Ahi1 antibody
      • AHI1_HUMAN antibody
      • Contatins SH3 and WD40 domains antibody
      • dJ71N10.1 antibody
      • DKFZp686J1653 antibody
      • FLJ14023 antibody
      • FLJ20069 antibody
      • JBTS3 antibody
      • Jouberin antibody
      • ORF1 antibody
      • OTTHUMP00000017263 antibody
      • OTTHUMP00000017265 antibody
      • OTTHUMP00000234456 antibody
      • OTTHUMP00000234654 antibody
      • OTTHUMP00000234656 antibody
      see all

    Anti-AHI1 antibody 图像

    • Detection of AHI1 by Western Blot of Immunprecipitate.
      An antibody to AHI1 at 1µg/ml staining AHI1 in HeLa whole cell lysate.
      Lane 1; Immunoprecipitated using ab117815 at 6µg/mg lysate.
      Lane 2; Immunoprecipitated using control IgG.
      1 mg of lysate was used for IP and 20% of IP was loaded. Detection utilised Chemiluminescence with a 3 second exposure.

    Anti-AHI1 antibody (ab117815)参考文献

    ab117815 has not yet been referenced specifically in any publications.

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