Anti-AGRP抗体[MM0085-32B12] (ab89114)

概述

  • 产品名称
    Anti-AGRP抗体[MM0085-32B12]
    参阅全部 AGRP 一抗
  • 描述
    小鼠单克隆抗体[MM0085-32B12] to AGRP
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human protein

性能

应用

Our Abpromise guarantee covers the use of ab89114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 15 kDa.

靶标

  • 功能
    Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
  • 组织特异性
    Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • 疾病相关
    Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • 序列相似性
    Contains 1 agouti domain.
  • 结构域
    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
  • 细胞定位
    Secreted. Golgi apparatus lumen.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Agouti related neuropeptide antibody
    • Agouti Related Protein Homolog antibody
    • Agouti-related protein antibody
    • Agrp antibody
    • AGRP_HUMAN antibody
    • AGRT antibody
    • ART antibody
    • ASIP2 antibody
    see all

实验方案

文献

ab89114 has not yet been referenced specifically in any publications.

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