概述

  • 产品名称
  • 描述
    山羊多克隆抗体to AGRP
  • 特异性
    This antibody is expected to recognise both reported isoforms (as represented by NP_001129; NP_015531).
  • 经测试应用
    适用于: IHC-FoFrmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide:

    (C)RKLGTAMNPCSRT

    , corresponding to C terminal amino acids 120-132 of Human AGRP

性能

应用

Our Abpromise guarantee covers the use of ab32882 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-FoFr Use a concentration of 0.05 - 0.1 µg/ml.

靶标

  • 功能
    Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
  • 组织特异性
    Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • 疾病相关
    Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • 序列相似性
    Contains 1 agouti domain.
  • 结构域
    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
  • 细胞定位
    Secreted. Golgi apparatus lumen.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Agouti related neuropeptide antibody
    • Agouti Related Protein Homolog antibody
    • Agouti-related protein antibody
    • Agrp antibody
    • AGRP_HUMAN antibody
    • AGRT antibody
    • ART antibody
    • ASIP2 antibody
    see all

图片

  • Immunohistochemical analysis of PFA-perfused frozen Human hypothalamus tissue, staining AGRP with ab32882 at 0.05 µg/ml. Antigen retrieval was performed by heat mediation in a citrate buffer (pH 6).

文献

ab32882 has not yet been referenced specifically in any publications.

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