概述

  • 产品名称Anti-Agrin抗体[AGR 131]
    参阅全部 Agrin 一抗
  • 描述
    小鼠单克隆抗体[AGR 131] to Agrin
  • 特异性Ab12362 detects all isoforms of agrin. This antibody recognizes all N1 isoforms but, consistent with the epitope mapping investigations, fails to see the N4 protein. Furthermore, the antibody will detect the X, Y and Z splice variants.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Recombinant rat agrin, C-terminal construct.

  • 表位Epitope is located near the 1st EGF-like repeat.

性能

应用

Our Abpromise guarantee covers the use of ab12362 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 208.6 kDa.

靶标

  • 相关性Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.
  • 细胞定位Secreted; extracellular space; extracellular matrix. Note: Synaptic basal lamina at the neuromuscular junction.
  • 数据库链接
  • 别名
    • AGRIN antibody
    • Agrin proteoglycan antibody
    • AGRN antibody
    • FLJ45064 antibody
    • OTTHUMP00000044043 antibody
    see all

Anti-Agrin antibody [AGR 131] (ab12362)参考文献

This product has been referenced in:
  • Smuder AJ  et al. Cervical spinal cord injury exacerbates ventilator-induced diaphragm dysfunction. J Appl Physiol (1985) 120:166-77 (2016). Read more (PubMed: 26472866) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"