Anti-Aflatoxin B1抗体[AFA-1] (ab1017)

概述

  • 产品名称
    Anti-Aflatoxin B1抗体[AFA-1]
  • 描述
    小鼠单克隆抗体[AFA-1] to Aflatoxin B1
  • 特异性
    This antibody recognizes Aflatoxin B1. The cross reactivity with other Aflatoxins has not been verified yet.
  • 经测试应用
    适用于: ELISAmore details
  • 免疫原

    Purified Aflatoxin B1

  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. 

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    PBS, pH7.2
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    单克隆
  • 克隆编号
    AFA-1
  • 同种型
    IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab1017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use a concentration of 5 µg/ml.

靶标

  • 相关性
    The aflatoxins are a group of closely related mycotoxins that are widely distributed in nature. The most important of the group is aflatoxin B1 (AFB1), which has a range of biological activities, including acute toxicity, teratogenicity, mutagenicity and carcinogenicity. In order for AFB1 to exert its effects, it must be converted to its reactive epoxide by the action of the mixed function mono-oxygenase enzyme systems (cytochrome P450-dependent) in the tissues (in particular, the liver) of the affected animal. This epoxide is highly reactive and can form derivatives with several cellular macromolecules, including DNA, RNA and protein. Cytochrome P450 enzymes may additionally catalyse the hydroxylation (to AFQ1 and AFM1) and demethylation (to AFP1) of the parent AFB1 molecule, resulting in products less toxic than AFB1. Conjugation of AFB1 to glutathione (mediated by glutathione S-transferase) and its subsequent excretion is regarded as an important detoxification pathway in animals. Aflatoxins are well recognized as a cause of liver cancer, but they have additional important toxic effects. Aflatoxin B1 is a potent hepatocarcinogenic and mutagenic mycotoxin of Aspergillus flavus.
  • 别名
    • AFB1 antibody

文献

ab1017 has not yet been referenced specifically in any publications.

客户评价及客户问答

This item is sold in a 250ug size. The stock concentration of the antibody is 1mg/ml. Therefore each vial purchased will contain 250ul of antibody.

Thank you for contacting us.

The product ab1017 does not contain any hazardous chemical e.g. Sodium Azide or Thimersol so this product should not be included in hazardous chemicals. However as this an antibody so general laboratory precautiona...

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Thank you very much for contacting us with your enquiry, and for your patience while I have been in touch with the production labs for more information about our aflatoxin antibodies.

We have three monoclonal antibodies against aflatoxin: ab6...

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Thank you for your email. At this time, we currently have one Aflatoxin B1 antibody, it is catalog # ab1017. The antibody in unconjugated; it is not labeled. However, we do carry a wide range of secondary antibodies which can be used with this primary,...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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